Over the past few decades there has been growing interest to develop novel drug delivery systems. The system uses to minimize drug degradation and loss, to prevent harmful side-effects and increase drug bioavailability. Among drug carriers one can name oil-in-oil emulsion. Oil-in-oil (O/O) emulsion could be useful for where some drugs are either unstable in the presence of water or are insoluble in water. The present work is to develop oil-in-oil emulsion for topical delivery of ketoconazole as antifungal drug which gives controlled release with anhydrous vehicle to deliver lipophilic or hydrolytically unstable drugs. The potential components of (O/O) emulsion were castor oil, silicone oil and surfactant, among the surfactant studied only silicone emulsifier was more effective in formulating castor-silicone emulsion. Optimization of formulation factor was achieved using Box-Behnken experimental design. The variables selected include phase volume ratio, surfactant concentration and stirring time. (O/O) emulsion prepared in very less time by hand stirring spontaneous mixing of both phases. Viscosity of formulation was found to be 167.51 cPs. The globule size was found to be 4.56 µm. volume distributions 8.18 µm through intensity distribution. Ketoconazole were solubilize in the internal castor oil phase and their release from emulsion across a dialysis membrane into phosphate buffer pH 5.5 was recorded 29.76% cumulative drug is released within a period of 8 hrs.
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